AMPK Activator Berberine is a natural plant-based compound found in several different plants, including Barberry (Berberis vulgaris). Berberine is known as a direct AMPK activator. The AMPK pathway, in short, is one of the things that happens during exercise, the expression of a set of genes known to promote longevity. Both human and animal studies show Berberine may have the potential to support healthy blood sugar levels, already in the normal range. Berberine may also help support healthy cholesterol, gut, brain, heart, and inflammation. Berberine is a general health and wellness supplement that has been used as a traditional herb for thousands of years.