KEY FINDINGS: We found NR could prevent liver fibrosis and reverse the existing liver fibrosis. NR inhibited the activation of LX-2 cells induced by TGF-β, activated Sirt1 and deacetylated Smad2/3. Sirt1 knockdown diminished the inhibiting effect of NR on LX-2 cells activation, and increased expressions of acetylated Smads. In conclusion, NR could prevent liver fibrosis via suppressing activation of hepatic stellate cells (HSCs). This protective effect was mediated by regulating the acetylation of Smads signaling pathway. Keep Reading....


Breakdowns in mitochondrial housekeeping provide another clue to Alzheimer’s culprit

March 13, 2019

Mitochondrial housekeeping alzheimer's

Researchers have zeroed in on the role of defects in mitophagy—a process in which cells clean out damaged or defective mitochondria—as a potential new treatment target for Alzheimer’s disease in experiments with animal models and lab specimens of human neurons. An international team of scientists led by NIA Intramural Research Program investigators in the Laboratory of Molecular Gerontology published their results in the March issue of Nature Neuroscience. Continue reading...

David Sinclair - The Future of Humanity | Xapiens Symposium

March 13, 2019

David Sinclair - tje future of humanity

Discussion of the future of humanity . The future of our species will be majorly influenced by the technical advancements and ethical paradigm shifts over the next several decades. Artificial intelligence, neural enhancement, gene editing, solutions for aging and interplanetary travel, and other emerging technologies are bringing sci-fi’s greatest ideas to reality. Watch the Video

Longevity and anti-aging research: ‘Prime time for an impact on the globe’

March 8, 2019

Research into longevity and healthy aging has progressed rapidly in recent years, but intense interest from the public, corporations, and the media has created an environment in which unfounded claims can be hard to separate from scientific facts.

In February, a group of 16 researchers from Harvard, MIT, and other institutions around the U.S. and Europe launched continue reading...


January 29, 2019

Check out this fascinating discussion with David Sinclair on the Joe Rogan Experience Podcast. The discussion ranges from the effects of NMN and Resveratrol to David Sinclair's daily routines and current clinical studies. It's a must watch!

Scientists identify new fuel-delivery route for cells

January 07, 2019

Scientists at Washington University School of Medicine in St. Louis have identified a previously unknown route for cellular fuel delivery, a finding that could shed light on the process of aging and the chronic diseases that often accompany it.

With age, cells gradually lose their ability to take in and process fuel. A cell that can’t fill its fuel tank, so to speak, can’t perform its proper functions. Researchers are interested in finding ways to boost the energy supply of aging cells in an effort to stave off the detrimental effects of the inevitable passage of time...

Slc12a8 is a nicotinamide mononucleotide transporter

January 7, 2019

NMN NAD+ slc12a8 is a nicotinamide mononucleotide transporter



Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of nicotinamide adenine dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels. How NMN is taken up into cells has not been entirely clear. Here we show that the Slc12a8 gene encodes a specific NMN transporter...contiue reading

Stunning anti-ageing breakthrough could see humans live to 150

  September 01, 2018

stunnging anti-agin breakthrough could see humans live to 150

An extraordinary new anti-ageing technique could see humans live to 150 years old and allow them to regrow their organs by 2020.

Harvard Professor David Sinclair and researchers from the University of New South Wales developed the new process, which involves reprogramming cells.

Dr Sinclair said the technique could allow people to regenerate organs, and even allow paralysis sufferers to move again, with human trials due within two years...contiue reading

Why Jeff Bezos is backing this Silicon Valley scientist who is working on a cure for aging

  August 29, 2018

According to Dr. Sinclair, "Senolytics delete zombie cells in the body which could treat age-related diseases and slow aging, the most common disease. Imagine taking a medicine every 10 years for rejuvenation." Read this insightful article following Ned David and his team and their research into senescent cells.

High protein intake is associated with low plasma NAD+ levels in a healthy human cohort

  August 16, 2018

High protein intake and reduced levels of the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD+) have both been independently associated with promotion of the ageing phenotype. However, it has not yet been shown whether these two independent observations are biochemically linked. To investigate this possibility...continue Reading

Longevity In A Bottle

  August 15, 2018

‘Tick, tock,’ goes the clock, and with each passing second, vitality silently slips away. The slow trace of wrinkles over smooth and supple skin, the nefarious creep of aches and pains in the muscles and joints, the ominous appearance of lesions and lumps...continue reading

David Sinclair at TEDMED Discussing Resveratrol, Longevity, Endurance, and Sirtuins

  July 2, 2018




Dr David Sinclair talks about longevity, Sirtuins and aging at TEDMED.

Watch the Video

Scientists Can Reverse DNA Aging in Mice

  March 23, 2018

Researchers have found a way to protect a mouse’s DNA from the damage that comes with aging, and they’re ready to test it in people.

Dr. David Sinclair, from Harvard Medical School, and his colleagues reveal their new findings in the latest issue of Science. They focused on an intriguing compound with anti-aging properties called NAD+, short for nicotinamide adenine dinucleotide...continue reading

Rewinding the Clock

  March 22, 2018

  There are currently several human clinical trials underway that are going to help answer this very question. Dr. Sinclair has been leading the charge in this field for years. Recent NMN trials in mice are very promising and show that more study is warranted. Scientists have reversed vascular atrophy, restored vessel growth in mice. Watch the video and read the article recently published on the Harvard Medical School website.

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

  August 24, 2016


The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans...continue reading